Urolithin A yog ib qho hnyuv metabolite ntawm ellagic acid nrog antioxidant thiab antiproliferative teebmeem; nws inhibits kev loj hlob ntawm T24 thiab Caco-2 hlwb nrog IC50 qhov tseem ceeb ntawm 43.9 thiab 49 μM, feem.

Lub cev thiab tshuaj muaj zog ntawm urolithin A

Urolithin A yog ib qho metabolite thib ob ntawm lub ntuj polyphenol compound ellagitannin. Cov kev tshawb fawb tshiab kawg tau pom tias urolithin A muaj cov haujlwm tseem ceeb hauv cov khoom siv roj ntsha, xws li tiv thaiv oxidation, tiv thaiv kab mob, tiv thaiv kev laus, tswj cov tshuaj estrogen / androgen thiab inducing mitochondrial autophagy. Yog li, urolithin A ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv thiab kho ntau yam kab mob, xws li mob qog noj ntshav, kab mob plawv, Alzheimer's disease, Parkinson's disease, ntshav qab zib, rog rog, osteoarthritis, thiab lwm yam.

Qhov chaw thiab cov yam ntxwv ntawm urolithin

Urolithin A (UroA) thiab urolithin B (UroB) yog thawj zaug cais tawm ntawm yaj lub raum pob zeb ua metabolites ntawm ellagic acid. Ntuj urolithin tsis muaj nyob rau hauv cov xwm, tab sis raws li ib tug metabolite ntawm ellagic tannin los yog ellagic acid, nws yog dav faib nyob rau hauv cov zis, quav thiab cov kua tsib ntawm cov tsiaj txhu xws li tib neeg, nas, nas, nyuj thiab npua. Espín et al. pom tias urolithin tuaj yeem ua kom muaj txiaj ntsig zoo rau lub zais zis thiab lub zais zis ntawm Iberian npua, tab sis tsis muaj qhov pom tseeb ntxiv hauv lwm cov ntaub so ntswg xws li nqaij, rog, raum, siab thiab lub plawv. Cov kev tshawb fawb soj ntsuam hauv cov nas thiab tib neeg tau pom tias urolithin thiab nws cov derivatives yog enriched nyob rau hauv cov ntaub so ntswg prostate thiab kuj muab faib nyob rau hauv tib neeg cov hnyuv.

Urolithin yog tsim los ntawm ellagic acid poob lub nplhaib lactone thiab maj mam dehydroxylating nws. Tom qab ellagic acid poob nws lub nplhaib lactone, urolithin M-5 (UroM-5) yog thawj zaug. UroM-5 yog dehydroxylated ntawm ntau txoj haujlwm los tsim ntau tetrahydroxy urolithin isomers xws li urolithin D (UroD) thiab urolithin M-6 (UroM-6). Tetrahydroxy urolithin poob ib pawg hydroxyl los tsim trihydroxy urolithins xws li urolithin C (UroC) thiab urolithin M-7 (UroM-7). Trihydroxy urolithin poob lwm pab pawg hydroxyl los tsim dihydroxy urolithins xws li UroA thiab urolithin A isomer (isoUroA), thiab thaum kawg monohydroxy urolithin B (UroB) tau txais. Ntxiv mus, isoUroA yooj yim rau dehydroxylate los tsim UroB dua UroA. García-Villalba thiab al. Nws siv nyob rau hauv vitro plab hnyuv microbial kev sim ua kom pom cov metabolites ntawm ellagic acid, UroM-5, UroM-6, UroM-7, UroC, thiab urolithin E (UroE), lees paub thawj zaug uas urolithin yog tsim nyob rau hauv qhov kev txiav txim ntawm plab hnyuv flora.

Urolithin A yog ib yam khoom ntawm cov hnyuv. Tom qab tib neeg lub cev noj zaub thiab txiv hmab txiv ntoo xws li pomegranates, berries thiab txiv ntoo, cov kab mob hauv plab hnyuv thiab cov phenolic antioxidants nplua nuj nyob rau hauv cov txiv hmab txiv ntoo thiab zaub saum toj no ua rau tsim urolithin A. Nyob rau hauv xyoo tas los no, qee qhov kev tshawb fawb preclinical tau taw qhia tias urolithin A pab. mitochondrial proliferation thiab ntxiv dag zog rau nws txoj haujlwm, yog li txhawb kev noj qab haus huv ntawm tes, thiab cov nyhuv tshwj xeeb yog qhov tseem ceeb hauv cov leeg, hlwb, pob qij txha thiab lwm qhov chaw.

Ntxiv cov txiaj ntsig ntawm urolithin A: poob phaus thiab visceral rog

Tsis tas li ntawd, urolithin A pab poob phaus. Ib qho kev sim tsiaj hauv xyoo 2020 tau pom tias pab pawg tshawb fawb tau pub cov nas rog rog hauv 4 txoj hauv kev: kev noj zaub mov zoo, noj zaub mov muaj roj, noj zaub mov muaj roj ntau ntxiv nrog urolithin A tom qab 10 lub lis piam, thiab noj cov rog rog ntxiv nrog urolithin B tom qab 10 lub lis piam. Qhov kawg tshwm sim yog tias ob pawg nas rog rog ntxiv nrog urolithin tau txo qis hauv qhov hnyav thiab visceral rog.