Lipoic acid yog ib coenzyme tam sim no nyob rau hauv mitochondria nrog molecular mis C8H14O2S2. Nws zoo ib yam li cov vitamins thiab tuaj yeem tshem tawm cov dawb radicals uas ua rau muaj kev laus sai thiab kab mob. Lipoic acid nkag mus rau hauv cov hlwb tom qab tau nqus los ntawm cov hnyuv hauv lub cev, thiab muaj ob qho tib si roj-soluble thiab dej-soluble zog. Lipoic acid belongs rau ib chav kawm ntawm cov ntsiab lus ntawm cov vitamins B. Nws yog ib qho kev loj hlob ntawm cov poov xab thiab qee cov kab mob. Nws ua lub luag haujlwm coenzyme hauv ntau lub enzyme system thiab catalyzes oxidative decarboxylation ntawm pyruvate rau acetic acid thiab oxidative decarboxylation ntawm α-ketoglutarate rau succinic acid. Intermediate transacylation.

Raws li ib tug coenzyme, lipoic acid plays lub luag hauj lwm nyob rau hauv ob qho tseem ceeb oxidative decarboxylation cov tshuaj tiv thaiv, uas yog, nyob rau hauv lub pyruvate dehydrogenase complex thiab α-ketoglutarate dehydrogenase complex, catalyzing tiam thiab hloov ntawm acyl pawg. Lipoic acid tuaj yeem lees txais pawg acyl thiab pawg acetyl ntawm pyruvate los tsim ib daim ntawv cog lus thioester, thiab tom qab ntawd hloov cov pawg acetyl mus rau sulfur atom ntawm coenzyme A molecule. Lub dihydrolipoamide tsim cov pab pawg neeg prosthetic tuaj yeem oxidized los ntawm dihydrolipoamide dehydrogenase (yuav tsum tau NAD +) los tsim oxidized lipoamide. Alpha-lipoic acid muaj ib tug disulfide tsib-ntiv nplhaib qauv nrog siab electron ceev, tseem ceeb electrophilicity thiab muaj peev xwm los teb nrog dawb radicals. Yog li ntawd, nws muaj cov khoom antioxidant thiab muaj kev saib xyuas kev noj qab haus huv siab heev thiab muaj txiaj ntsig kho mob (xws li Anti-fatty daim siab thiab txo cov plasma cholesterol).

Lipoic acid feem ntau yog siv los tiv thaiv cov piam thaj los ntawm kev khi rau cov protein, uas yog, nws muaj "anti-glycation", yog li nws tuaj yeem yooj yim stabilize cov ntshav qab zib. Yog li ntawd, yav tas los nws tau siv los ua cov vitamin los txhim kho cov metabolism thiab raug coj los ntawm cov neeg mob siab thiab ntshav qab zib. . Txhim kho lub siab ua haujlwm Lipoic acid muaj kev ua haujlwm ntawm kev ua kom lub siab ua haujlwm, yog li nws kuj tau siv los ua tshuaj tua kab mob rau cov zaub mov lom lossis tshuaj lom hlau thaum ntxov.

Rov qab los ntawm Fatigue Vim lipoic acid tuaj yeem ua rau lub zog metabolism hauv lub zog thiab hloov cov zaub mov noj mus rau hauv lub zog, nws tuaj yeem tshem tawm kev qaug zog sai thiab ua rau lub cev tsis nkees. Txhim kho Dementia Cov khoom molecules ntawm lipoic acid yog me me, yog li nws yog ib qho ntawm ob peb cov as-ham uas tuaj yeem ncav cuag lub hlwb. Nws kuj tseem tuav cov haujlwm antioxidant hauv lub hlwb, thiab tseem suav tias yog qhov ua tau zoo hauv kev txhim kho dementia.

Alpha lipoic acid yog ntau yam antioxidant. Vim nws yog dej-soluble thiab fat-soluble. Qhov no txhais tau tias nws muaj ntau yam teebmeem, ncav cuag txhua lub cell hauv lub cev los tiv thaiv cov kabmob ntawm cov dawb radical puas. Raws li cov tshuaj antioxidant, alpha lipoic acid tuaj yeem muab qee cov txiaj ntsig hauv qab no: Pab kom yaj cov tshuaj lom xws li mercury thiab arsenic hauv daim siab los ntawm kev tsim cov glutathione. Txhawb kev tsim dua tshiab ntawm qee cov antioxidants, tshwj xeeb tshaj yog cov vitamins E, C, glutathione thiab coenzyme Q10. Ua lub luag haujlwm tseem ceeb hauv kev hloov cov piam thaj mus rau hauv lub zog. Pab txhim kho lub sijhawm luv thiab lub sijhawm ntev kev nco.